| Title | A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System |
| Author | Johannes W.de Jong 1 6 Seyedeh Atiyeh Afjei 1 6 Iskra Pollak Dorocic 1 James R.Peck 1 Christine Liu 1 Christina K.Kim 2 Lin Tian 3 Karl Deisseroth 4 5 Stephan Lammel 1 7 |
| Affiliation(s) | 1 Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
2 Neuroscience Program, Stanford University, Stanford, CA 94305, USA
3 Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA 95616, USA
4 Departments of Bioengineering and Psychiatry, Stanford University, Stanford, CA 94305, USA
5 Howard Hughes Medical Institute, USA |
| Published | Neuron November 2018 https://doi.org/10.1016/j.neuron.2018.11.005
|
| Keyword | dopamine ventral tegmental area nucleus accumbens aversion reward lateral hypothalamus dorsal raphe |
| Snippet | |
| Abstract | Ventral tegmental area (VTA) dopamine (DA) neurons play a central role in mediating motivated behaviors, but the circuitry through which they signal positive and negative motivational stimuli is incompletely understood. Using in vivo fiber photometry, we simultaneously recorded activity in DA terminals in different nucleus accumbens (NAc) subnuclei during an aversive and reward conditioning task. .. |
